![]() There have been several suggestions of methods to solve these challenges, including co-administration with adjuvants. ![]() These include vanillin, ferulic acid,ġ2 feruloyl methane, 2-hydroxy-6-(4-hydroxy-3-methoxyphenyl)-4-oxohexa-2,5-dienal,ġ2 and 4-[(1e)-3-(propan-2-yloxy)prop-1-en-1-yl)guaiacol.ġ4 In addition, numerous pharmacokinetic evaluations have indicated the poor absorption, low solubility, rapid metabolism and elimination as well as poor bioavailability properties of curcumin. Moreover, this unstable compound is known to easily degrade into others,ġ0 and a total of eight have been reported to date. The facts and opinions on the biological effects of curcumin as a drug candidate indicate that it is a PAIN (pan-assay interference) compound or IMP (invalid metabolic panacea). Furthermore, there are reports on the promising anti-Alzheimer, as well as anticancer properties of curcumin, and its antagonistic effects against other degenerative diseases.ħ The curcumin component is also a non-toxic compound, as no toxicity has been reported following the administration of high doses to animals.Ĩ Previous reports have shown biological activities related to cancer, including lymphomas, breast, prostate, cervical, lung and colorectal cancers, alongside leukemia.Ĥ There are numerous pathways involved in regulation, including p53, BAX, cyclin D1, various BCL, p21, p27, AKT, COX-2, protein kinase, and others. These include the application of curcumin as an antioxidant, antibacterial, antifungal, antiviral, anti-inflammatory, and anti-angiogenic agent. In vitro to develop the numerous potentials in treating various diseases. Traditionally, a large number of people in India, China, Indonesia and other Asian countries have applied turmeric powder in therapeutic herbs and as a food additive.ĥ The curcumin (diferuloylmethane) constituent is a tautomeric compound known to exist as an enolic form in organic solvents, and in keto form in water.Ħ The wide range of biological activities are currently being tested Curcumin is a compound derived from turmeric (Ĭurcuma longa), which is responsible for the yellow rhizome extract coloration.
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